Rad51 replication fork recruitment is required for DNA damage tolerance

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Rad51 replication fork recruitment is required for DNA damage tolerance.

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Proteins essential for homologous recombination play a pivotal role in the repair of DNA double strand breaks, DNA inter-strand crosslinks and replication fork stability. Defects in homologous recombination also play a critical role in the development of cancer and the sensitivity of these cancers to chemotherapy. RAD51, an essential factor for homologous recombination and replication fork prot...

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BRG1 co-localizes with DNA replication factors and is required for efficient replication fork progression

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Damaged DNA templates provide an obstacle to the replication fork and can cause genome instability. In eukaryotes, tolerance to damaged DNA is mediated largely by the RAD6 pathway involving ubiquitylation of the DNA polymerase processivity factor PCNA. Whereas monoubiquitylation of PCNA mediates error-prone translesion synthesis (TLS), polyubiquitylation triggers an error-free pathway. Both bra...

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ژورنال

عنوان ژورنال: The EMBO Journal

سال: 2013

ISSN: 0261-4189,1460-2075

DOI: 10.1038/emboj.2013.73